Adrenergic activation attenuates astrocyte swelling induced by hypotonicity and neurotrauma
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چکیده
منابع مشابه
Apolipoprotein E attenuates beta-amyloid-induced astrocyte activation.
A common feature of Alzheimer's disease pathology is an abundance of activated glia, indicative of an inflammatory reaction in the brain. The relationship between glial activation and neurodegeneration is not known, although several cytokines and inflammatory mediators produced by activated glia have the potential to initiate or exacerbate the progression of neuropathology. As beta-amyloid (A b...
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Astrocytes are one of the most abundant cell types in the mammalian central nervous system (CNS), and astrocyte swelling is the primary event associated with brain edema. Glutamate, the principal excitatory amino acid neurotransmitter in the CNS, is released at high levels after brain injury including cerebral ischemia. This leads to astrocyte swelling, which we previously demonstrated is relat...
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ژورنال
عنوان ژورنال: Glia
سال: 2016
ISSN: 0894-1491
DOI: 10.1002/glia.22981